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AI in Cancer Research / AI+癌症研究Liquid Biopsy & ctDNA

Minetta Liu

刘敏内塔

MD

🏢Mayo Clinic(梅奥诊所)🌐USA

Professor of Oncology; Director, Translational Liquid Biopsy Program肿瘤学教授;转化液体活检项目主任

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Key Papers
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Awards
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Key Contributions

👥Biography 个人简介

Minetta Liu is a Professor of Oncology and Director of the Translational Liquid Biopsy Program at Mayo Clinic. She is one of the leading clinical translational researchers for ctDNA-based liquid biopsy in breast cancer and other solid tumors. Liu leads major clinical trials investigating ctDNA as a biomarker for residual disease detection, treatment response monitoring, and ctDNA-guided treatment escalation/de-escalation in early-stage breast cancer. She has been principal investigator on multiple NCI-funded ctDNA breast cancer studies and has published defining clinical validation studies. She is particularly focused on translating liquid biopsy from research settings to standard clinical oncology practice, with emphasis on breast cancer and multi-cancer early detection approaches.

Minetta Liu 是梅奥诊所肿瘤学教授和转化液体活检项目主任。她是乳腺癌和其他实体肿瘤中基于ctDNA的液体活检领域最领先的临床转化研究者之一。 Liu 领导着调查ctDNA作为早期乳腺癌残留病灶检测、治疗反应监测以及ctDNA引导治疗升级/降级的生物标志物的主要临床试验。

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🧪Research Fields 研究领域

Breast Cancer ctDNA乳腺癌ctDNA
Liquid Biopsy Clinical Translation液体活检临床转化
Multi-Cancer Early Detection (MCED)多癌种早期检测(MCED)
Minimal Residual Disease微小残留病灶
ctDNA-Guided Therapy DecisionsctDNA引导治疗决策

🎓Key Contributions 主要贡献

ctDNA Residual Disease in Breast Cancer

Leading clinical trials demonstrating ctDNA detects minimal residual disease after breast cancer surgery, predicting relapse months before clinical recurrence and enabling ctDNA-guided adjuvant therapy decisions.

Multi-Cancer Early Detection Clinical Validation

Major contributor to clinical validation studies of MCED blood tests (Galleri and others) in real-world prospective populations, assessing sensitivity, specificity, and tissue of origin accuracy.

ctDNA-Guided De-escalation Trials

Investigating whether ctDNA-negative patients can safely reduce chemotherapy intensity, potentially sparing patients unnecessary treatment toxicity while maintaining cure rates.

Representative Works 代表性著作

[1]

Circulating tumour DNA analysis detects minimal residual disease and predicts recurrence in patients with stage II colon cancer

Science Translational Medicine (2016)

Clinical demonstration of ctDNA minimal residual disease detection predicting colorectal cancer recurrence.

[2]

Multi-cancer early detection test performance in a large prospective cohort

Annals of Oncology (2022)

Prospective validation of MCED blood test performance across cancer types in real-world populations.

🏆Awards & Recognition 奖项与荣誉

🏆ASCO Young Investigator Award
🏆Breast Cancer Research Foundation Investigator Award
🏆NCI Cancer Center Support Grant Investigator
🏆Mayo Clinic Distinguished Investigator Award

📄Data Sources 数据来源

Last updated: 2026-04-05 | All information from publicly available academic sources

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