Howard Y. Chang
张育荣
MD, PhD
Professor of Dermatology; Director, Center for Personal Dynamic Regulomes皮肤病学教授；个人动态调控组中心主任
👥Biography 个人简介
Pioneer in lncRNA biology who discovered HOTAIR and its role in chromatin remodeling and cancer metastasis. Co-inventor of ATAC-seq for chromatin accessibility profiling. Member of the National Academy of Sciences.
🧪Research Fields 研究领域
🎓Key Contributions 主要贡献
HOTAIR lncRNA
Discovered that lncRNA HOTAIR reprograms chromatin state to promote cancer invasiveness and metastasis, establishing lncRNAs as drivers of cancer epigenetics.
ATAC-seq Technology
Co-developed ATAC-seq, a widely adopted method to map open chromatin in single cells, enabling cancer epigenome profiling at unprecedented resolution.
Representative Works 代表性著作
The RNA component of human telomerase
Science (2007)
Foundational work on RNA-protein interactions relevant to cancer cell immortalization.
Long noncoding RNA HOTAIR reprograms chromatin state to promote cancer metastasis
Nature (2010)
Demonstrated that HOTAIR drives breast cancer metastasis via Polycomb-mediated chromatin silencing.
Transposition of native chromatin for fast and sensitive epigenomic profiling of open chromatin, DNA-binding proteins and nucleosome position (ATAC-seq)
Nature Methods (2013)
Introduced ATAC-seq method now standard in cancer epigenomics.
🏆Awards & Recognition 奖项与荣誉
📄Data Sources 数据来源
Last updated: 2026-01-15 | All information from publicly available academic sources
Related Experts 相关专家
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Kun-Hsing Yu
Harvard Medical School; Brigham and Women's Hospital
Ziad Obermeyer
University of California, Berkeley; UC San Francisco
Andrew H. Beck
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