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research / researchcancer immunology

Glen Barber

格伦·巴伯

PhD

🏢University of Miami Miller School of Medicine(迈阿密大学米勒医学院)🌐USA

Professor and Chairman, Department of Cell Biology; Director, Sheila and David Fuente Graduate Program细胞生物学系主任教授

88
h-index
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Key Papers
4
Awards
3
Key Contributions

👥Biography 个人简介

Glen Barber is the discoverer of the STING (Stimulator of Interferon Genes) pathway, one of the most transformative findings in innate immunity of the past two decades. His identification of STING as the central signaling hub for cytosolic DNA sensing revolutionized understanding of how tumors are recognized by the innate immune system and enabled an entirely new class of cancer immunotherapy drugs — STING agonists — now in multiple clinical trials.

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🧪Research Fields 研究领域

cGAS-STING PathwaycGAS-STING通路
Innate Immune Sensing先天免疫感知
Type I Interferon in CancerI型干扰素与癌症
STING AgonistsSTING激动剂
DNA Sensing and Tumor ImmunityDNA感知与肿瘤免疫

🎓Key Contributions 主要贡献

STING Discovery

Identified STING (TMEM173) as the critical innate immune adapter that senses cyclic dinucleotides produced by cGAS upon detection of cytosolic dsDNA from dying tumor cells.

STING in Anti-Tumor Immunity

Demonstrated that spontaneous tumor rejection requires STING-dependent type I IFN production by dendritic cells, linking innate DNA sensing to adaptive anti-tumor T cell responses.

STING Agonist Drug Development

Led preclinical development of synthetic STING agonists (cyclic dinucleotide analogs) that induce tumor regression when injected intratumorally, providing rationale for clinical trials.

Representative Works 代表性著作

[1]

STING is an endoplasmic reticulum adaptor that facilitates innate immune signalling

Nature (2008)

Original STING discovery paper establishing its role as the ER-resident signaling hub for innate immune activation downstream of cytosolic DNA detection.

[2]

STING-dependent cytosolic DNA sensing promotes radiation-induced type I interferon-dependent anti-tumor immunity

Immunity (2014)

Showed radiation-induced tumor DNA release activates STING in dendritic cells, bridging radiotherapy with innate immune activation and T cell priming.

🏆Awards & Recognition 奖项与荣誉

🏆Vilcek Prize for Creative Promise in Biomedical Science
🏆AAI Meritorious Career Award
🏆Howard Hughes Medical Institute Investigator
🏆NIH MERIT Award

📄Data Sources 数据来源

Institution

Last updated: 2026-01-15 | All information from publicly available academic sources

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