Axel Ullrich
阿克塞尔·乌尔里希
PhD
Director Emeritus名誉主任
👥Biography 个人简介
Axel Ullrich is a molecular biologist who performed the pioneering cloning of EGFR and HER2 (ErbB-2) receptor tyrosine kinases, providing the molecular tools that enabled all subsequent targeted therapy development against these receptors. His cloning of EGFR at Genentech in 1984 established the sequence basis for EGFR inhibitor development, and his cloning of HER2/neu demonstrated sequence homology with EGFR and established the ErbB receptor family. Ullrich also cloned the insulin receptor kinase, establishing the structural basis for receptor tyrosine kinase signaling. His foundational molecular biology work made the entire field of receptor tyrosine kinase targeted oncology possible.
🧪Research Fields 研究领域
🎓Key Contributions 主要贡献
EGFR Molecular Cloning
Performed the first complete molecular cloning of the EGFR gene at Genentech in 1984, establishing the sequence and domain structure that enabled rational design of EGFR-targeting antibodies and small molecule inhibitors.
HER2 Receptor Tyrosine Kinase Cloning
Cloned HER2/ErbB-2 and established its sequence homology with EGFR, defining the ErbB receptor family and providing the molecular basis for development of trastuzumab and subsequent HER2-targeted agents.
Representative Works 代表性著作
Human Epidermal Growth Factor Receptor cDNA Sequence and Aberrant Expression in Amplified A431 Epidermoid Carcinoma Cells
Nature (1984)
First complete EGFR gene cloning.
A New Proto-Oncogene with Tyrosine Kinase Activity from Human Placenta
Nature (1985)
Cloning of insulin receptor establishing RTK kinase domain structure.
🏆Awards & Recognition 奖项与荣誉
📄Data Sources 数据来源
Last updated: 2026-01-15 | All information from publicly available academic sources
Related Experts 相关专家
Faisal Mahmood
Brigham and Women's Hospital; Harvard Medical School
Kun-Hsing Yu
Harvard Medical School; Brigham and Women's Hospital
Ziad Obermeyer
University of California, Berkeley; UC San Francisco
Andrew H. Beck
PathAI; Harvard Medical School (formerly)
关注 阿克塞尔·乌尔里希 的研究动态
Follow Axel Ullrich's research updates
留下邮箱，当我们发布与 Axel Ullrich（Max Planck Institute of Biochemistry）相关的新研究或访谈时，我们会通知你。
Explore More Experts
Discover the researchers shaping the future of cancer treatment