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research / researchovarian cancer immune evasion

George Coukos

乔治·科科斯

MD, PhD

🏢University of Lausanne / Lausanne University Hospital (CHUV)(洛桑大学/洛桑大学医院)🌐Switzerland

Director, Ludwig Institute for Cancer Research and Chief, Oncology路德维希癌症研究所主任及肿瘤学首席

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Key Papers
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Awards
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Key Contributions

👥Biography 个人简介

George Coukos is a tumor immunologist who pioneered the demonstration that tumor-infiltrating lymphocytes (TILs) predict survival in ovarian cancer, providing one of the first direct clinical evidence that immune surveillance affects human cancer outcomes and prefiguring the era of immunotherapy. He leads the Ludwig Institute for Cancer Research in Lausanne and has built comprehensive T cell and immunotherapy programs. Coukos has characterized how the ovarian cancer TME creates an immunosuppressive niche through TGF-beta, VEGF, and regulatory T cells, and leads clinical trials of CAR-T cells targeting tumors expressing folate receptor alpha and mesothelin.

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🧪Research Fields 研究领域

ovarian cancer tumor infiltrating lymphocytes卵巢癌肿瘤浸润淋巴细胞
tumor immunology TME肿瘤免疫学TME
CAR-T solid tumorsCAR-T实体瘤
T cell traffickingT细胞迁移
immunotherapy ovarian cancer卵巢癌免疫治疗

🎓Key Contributions 主要贡献

TIL Survival Benefit in Ovarian Cancer

Demonstrated that tumor-infiltrating lymphocytes (TILs) are an independent predictor of improved survival in ovarian cancer patients, providing the first strong clinical evidence that immune surveillance affects human cancer outcomes.

Ovarian Cancer TME Immunosuppression

Characterized mechanisms of immunosuppressive TME in ovarian cancer including VEGF-mediated T cell exclusion, TGF-beta effects, and regulatory T cell enrichment, identifying multiple targets for TME reprogramming.

Representative Works 代表性著作

[1]

Intratumoral T Cells, Recurrence, and Survival in Epithelial Ovarian Cancer

New England Journal of Medicine (2003)

Landmark demonstration of TIL survival benefit in ovarian cancer.

[2]

Vascular Endothelial Growth Factor Inhibits the Development of Dendritic Cells and Dramatically Affects the Differentiation of Multiple Hematopoietic Lineages in Vivo

Blood (1999)

VEGF-mediated immune suppression mechanisms.

🏆Awards & Recognition 奖项与荣誉

🏆SITC Presidential Award
🏆ESGO Award for Excellence in Gynaecologic Tumor Immunology
🏆William B. Coley Award

📄Data Sources 数据来源

Institution

Last updated: 2026-01-15 | All information from publicly available academic sources

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