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research / researchCancer RNA Biology

George A. Calin

乔治·卡林

MD, PhD

🏢The University of Texas MD Anderson Cancer Center(德克萨斯大学MD安德森癌症中心)🌐USA

Professor, Department of Translational Molecular Pathology; Marnie Rose Foundation Endowed Professor转化分子病理学系教授；马尼·罗斯基金会冠名教授

95
h-index
3
Key Papers
3
Awards
2
Key Contributions

👥Biography 个人简介

Co-discoverer of miRNA involvement in cancer (CLL with Croce) and pioneer of non-coding RNA cancer biomarkers. Identified ultra-conserved regions and non-coding RNAs as novel cancer-linked entities. Leads liquid biopsy RNA biomarker research.

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🧪Research Fields 研究领域

microRNA Cancer BiomarkersmicroRNA癌症生物标志物
Non-Coding RNA Cancer癌症非编码RNA
Liquid Biopsy RNA液体活检RNA
CLL Molecular PathologyCLL分子病理学
Ultra-Conserved Regions超保守区域

🎓Key Contributions 主要贡献

miRNA as Cancer Biomarkers

Demonstrated that circulating miRNAs in blood serve as stable, sensitive cancer biomarkers enabling non-invasive detection, pioneering the liquid biopsy RNA field.

Ultra-Conserved Regions

Discovered ultra-conserved genomic regions that encode non-coding RNAs altered in human cancers, expanding the non-coding RNA cancer landscape.

Representative Works 代表性著作

[1]

Frequent deletions and down-regulation of micro-RNA genes miR15 and miR16 at 13q14 in CLL

PNAS (2002)

Co-authored landmark paper establishing miRNA deletions in CLL.

[2]

Human microRNA genes are frequently located at fragile sites and genomic regions involved in cancers

PNAS (2004)

Systematic mapping showing miRNA genes co-localize with cancer-associated genomic fragile sites.

[3]

Circulating microRNAs as stable blood-based markers for cancer detection

PNAS (2008)

Established that serum miRNAs are stable and detectable, validating them as liquid biopsy biomarkers.

🏆Awards & Recognition 奖项与荣誉

🏆European Association for Cancer Research Award
🏆Romanian Academy Member
🏆MDACC President's Award

📄Data Sources 数据来源

Institution

Last updated: 2026-01-15 | All information from publicly available academic sources

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