Frédéric Piscuoglio
弗雷德里克·皮斯科格利奥
PhD
Associate Professor, Department of Biomedicine, Cancer Biology Group生物医学系副教授，癌症生物学研究组
👥Biography 个人简介
Dr. Frédéric Piscuoglio is a leading cancer genomics researcher at the University of Basel. His work characterizing the molecular evolution of breast cancer and salivary gland tumors using whole-genome sequencing has revealed novel drivers and therapeutic targets in rare and common cancers.
🧪Research Fields 研究领域
🎓Key Contributions 主要贡献
Breast Cancer Genomic Landscape
Performed comprehensive whole-genome and transcriptome analyses of breast cancer subtypes, uncovering mutational signatures, structural variants, and clonal evolution patterns driving heterogeneity.
Salivary Gland Tumor Genomics
Characterized the genomic landscape of rare salivary gland carcinomas including adenoid cystic carcinoma, identifying MYB fusions and novel druggable alterations in these understudied tumors.
Tumor Heterogeneity and Evolution
Applied multi-region sequencing and single-cell approaches to map clonal evolution in breast cancer, linking genomic diversity to therapy resistance and metastatic potential.
Representative Works 代表性著作
Whole-genome sequencing of matched primary and metastatic breast cancers
Nature Genetics (2016)
Revealed somatic evolution during breast cancer metastasis, identifying late-arising driver mutations and clonal selection patterns relevant to treatment resistance.
Genomic landscape of adenoid cystic carcinoma of the breast
Journal of Pathology (2017)
First comprehensive genomic characterization of breast adenoid cystic carcinoma, establishing it as a MYB-NFIB-driven entity with distinct biology from conventional breast cancer.
Mutational landscape of metaplastic breast carcinoma
npj Breast Cancer (2019)
Identified PI3K pathway and Wnt signaling alterations in metaplastic breast carcinoma, providing the genomic rationale for targeted therapy trials in this chemoresistant subtype.
🏆Awards & Recognition 奖项与荣誉
📄Data Sources 数据来源
Last updated: 2026-01-15 | All information from publicly available academic sources
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