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research / researchCancer RNA Biology

Frank J. Slack

弗兰克·斯莱克

PhD

🏢Harvard Medical School / Beth Israel Deaconess Medical Center(哈佛医学院/贝斯以色列女执事医疗中心)🌐USA

Professor of Pathology; Director, Institute for RNA Medicine病理学教授；RNA医学研究所所长

72
h-index
3
Key Papers
3
Awards
2
Key Contributions

👥Biography 个人简介

Leading microRNA cancer researcher known for elucidating miR-21 as a potent oncomiR in lung and other cancers. Pioneered anti-miR therapeutic strategies and founded the Institute for RNA Medicine at Harvard/BIDMC.

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🧪Research Fields 研究领域

microRNA in Cancer癌症中的microRNA
miR-21 OncologymiR-21肿瘤学
Anti-miR Therapeutics抗miR治疗
Lung Cancer RNA肺癌RNA
RNA-based Biomarkers基于RNA的生物标志物

🎓Key Contributions 主要贡献

miR-21 in Cancer

Established miR-21 as a key oncogenic microRNA overexpressed in multiple cancers and driving tumor growth by repressing PTEN and PDCD4 tumor suppressors.

Anti-miR Therapeutics

Demonstrated that anti-miR oligonucleotides can suppress oncomiRs in vivo, laying groundwork for RNA-based cancer therapeutics now in clinical development.

Representative Works 代表性著作

[1]

A microRNA in a multiple-turnover RNAi enzyme complex

Science (2004)

Early mechanistic work on microRNA incorporation into RISC complex.

[2]

MicroRNA-21 is an antiapoptotic factor in human glioblastoma cells

Cancer Research (2005)

First demonstration of miR-21 as an oncomiR protecting cancer cells from apoptosis.

[3]

Oncomir addiction in an in vivo model of microRNA-21-induced pre-B-cell lymphoma

Nature (2010)

In vivo evidence that miR-21 drives lymphomagenesis and tumors regress upon miR-21 inhibition.

🏆Awards & Recognition 奖项与荣誉

🏆American Cancer Society Research Professor
🏆NIH Outstanding Investigator Award
🏆Harvard Medical School Mentoring Award

📄Data Sources 数据来源

Institution

Last updated: 2026-01-15 | All information from publicly available academic sources

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