Eunice Wang
王玉洁
MD
Professor and Chief, Leukemia Service白血病科教授兼主任
👥Biography 个人简介
Chief of the Leukemia Service at Roswell Park, specializing in AML with a focus on FLT3-mutant disease and leukemia stem cell biology. She leads translational and clinical studies integrating novel targeted agents with standard and experimental backbones to overcome resistance.
🧪Research Fields 研究领域
🎓Key Contributions 主要贡献
FLT3 Inhibitor Resistance Mechanisms
Elucidated molecular mechanisms of acquired resistance to FLT3 inhibitors in AML, guiding development of next-generation inhibitors and rational combination strategies to overcome primary and secondary resistance.
Novel Combination Therapy in AML
Led investigator-initiated trials combining FLT3 inhibitors with venetoclax, hypomethylating agents, and immunotherapy, expanding response rates and durability in relapsed/refractory and frontline settings.
Representative Works 代表性著作
Mechanisms of resistance to FLT3 inhibitors in AML
Blood Cancer Journal (2019)
Systematic characterization of on-target and off-target resistance mechanisms, providing a roadmap for next-generation FLT3-targeting strategies and combination therapy design.
Gilteritinib combined with azacitidine or low-dose cytarabine in newly diagnosed FLT3-mutated AML
Leukemia (2021)
Phase Ib/II study demonstrating high composite complete remission rates with gilteritinib-based combinations, informing ongoing Phase III confirmatory trials.
🏆Awards & Recognition 奖项与荣誉
📄Data Sources 数据来源
Last updated: 2026-01-15 | All information from publicly available academic sources
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