Ernst Lengyel
恩斯特·伦杰尔
MD, PhD
Arthur L. and Lee G. Herbst Professor; Chief, Section of Gynecologic OncologyArthur L.和Lee G. Herbst讲席教授；妇科肿瘤学科主任
👥Biography 个人简介
Ernst Lengyel, MD, PhD is the Arthur L. and Lee G. Herbst Professor and Chief of Gynecologic Oncology at the University of Chicago, renowned for his groundbreaking research into the biology of ovarian cancer metastasis and the role of the omental tumor microenvironment in peritoneal dissemination. His laboratory has made seminal discoveries demonstrating that adipocytes in the omentum provide lipid nutrients to ovarian cancer cells that fuel metastatic colonization, a discovery that has opened new therapeutic avenues targeting cancer cell metabolism. Dr. Lengyel's translational program bridges fundamental discoveries in tumor biology with novel biomarker and drug target identification.
🧪Research Fields 研究领域
🎓Key Contributions 主要贡献
Omental Adipocyte-Cancer Cell Crosstalk
Discovered that omental adipocytes transfer lipids to ovarian cancer cells through a lipolysis-driven mechanism, providing metabolic fuel for metastatic colonization of the peritoneum—a landmark discovery published in Nature Medicine that opened new therapeutic avenues in ovarian cancer metabolism.
Peritoneal Metastasis Mechanisms
Characterized the molecular mechanisms by which ovarian cancer cells attach to, invade, and colonize the omental and peritoneal mesothelial surface, identifying matrix metalloproteinase activity and mesothelial cell retraction as critical steps in early metastasis.
Early Detection Biomarker Discovery
Leads programs to identify protein and metabolomic biomarkers in blood and peritoneal fluid that can detect ovarian cancer at earlier, more curable stages, with a focus on multi-analyte panels outperforming CA-125 alone.
Representative Works 代表性著作
Adipocyte-Induced Epithelial-to-Mesenchymal Transition in Ovarian Cancer Cells
Nature Medicine (2011)
Seminal study revealing lipid transfer from omental adipocytes to ovarian cancer cells as a mechanism driving metastatic colonization.
Mesothelial Cells Create a Permissive Microenvironment for Ovarian Cancer Metastasis
Cancer Cell (2019)
Demonstrated how mesothelial cell remodeling and metabolic reprogramming facilitate peritoneal dissemination of ovarian cancer.
🏆Awards & Recognition 奖项与荣誉
📄Data Sources 数据来源
Last updated: 2026-01-15 | All information from publicly available academic sources
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