Eric Bouffet
埃里克·布费
MD
Head of Paediatric Haematology/Oncology, Neuro-Oncology Program Director儿科血液/肿瘤科主任，神经肿瘤项目主任
👥Biography 个人简介
Professor Eric Bouffet is a world leader in pediatric neuro-oncology originally trained in France and now heading SickKids' program in Toronto. He pioneered BRAF-targeted therapy for pediatric low-grade glioma and led pivotal trials transforming survival for children with brain tumors.
🧪Research Fields 研究领域
🎓Key Contributions 主要贡献
BRAF-Targeted Therapy in Pediatric Glioma
Led foundational clinical work establishing BRAF/MEK inhibition as effective targeted therapy for BRAF V600E-mutated pediatric low-grade gliomas, offering chemotherapy-free options.
Medulloblastoma Risk Stratification
Advanced molecular subgroup characterization of medulloblastoma and contributed to reduced-dose radiotherapy strategies for average-risk patients, decreasing long-term neurotoxicity.
Global Pediatric Neuro-Oncology Leadership
Co-led the International Society of Paediatric Oncology (SIOPE/SIOP) brain tumor committees, harmonizing international treatment protocols and advancing cooperative trial design.
Representative Works 代表性著作
Vemurafenib in Pediatric Patients with BRAF V600E–Mutated High-Grade Glioma
Pediatric Blood & Cancer (2018)
Clinical evidence for BRAF V600E inhibitor activity in pediatric high-grade glioma, supporting targeted therapy in a previously chemorefractory population.
Dabrafenib plus trametinib in pediatric BRAF V600–mutant low-grade glioma
New England Journal of Medicine (2023)
LOGGIC/FIREFLY-1 trial demonstrating superior response rates with BRAF+MEK inhibition over chemotherapy in pediatric BRAF-mutant low-grade glioma.
Molecular subgroups of medulloblastoma: long-term outcomes and treatment implications
Lancet Oncology (2016)
Long-term survival analysis defining prognostic impact of WNT, SHH, Group 3 and Group 4 medulloblastoma subgroups with implications for risk-adapted therapy.
🏆Awards & Recognition 奖项与荣誉
📄Data Sources 数据来源
Last updated: 2026-01-15 | All information from publicly available academic sources
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