Eicke Latz
艾克·拉茨
MD, PhD
Director, Institute of Innate Immunity; Professor of Immunology先天免疫研究所所长，免疫学教授
👥Biography 个人简介
Eicke Latz is a world authority on the NLRP3 inflammasome and innate immune sensing mechanisms. His laboratory at the University of Bonn has made landmark contributions to understanding how the NLRP3 inflammasome is activated by danger signals in the tumor microenvironment, producing IL-1β and IL-18 that shape anti-tumor immunity. His work on pyroptosis and gasdermin D pore formation has revealed new mechanisms of immunogenic cancer cell death.
🧪Research Fields 研究领域
🎓Key Contributions 主要贡献
NLRP3 Activation Mechanisms
Elucidated the two-signal model of NLRP3 activation and defined potassium efflux as the universal proximal trigger, providing mechanistic understanding relevant to tumor-induced inflammation.
Pyroptosis in Anti-Tumor Immunity
Showed that gasdermin D-mediated pyroptosis of tumor cells releases DAMPs that activate dendritic cells and promote anti-tumor CD8+ T cell responses.
Inflammasome-Targeted Therapy
Developed selective NLRP3 inhibitors (MCC950 analogs) and defined contexts where inflammasome blockade can reduce tumor-promoting chronic inflammation while sparing anti-tumor immunity.
Representative Works 代表性著作
Activation and regulation of the inflammasomes
Nature Reviews Immunology (2013)
Comprehensive review of NLRP3 inflammasome biology cited over 3,000 times, defining the mechanistic framework for innate immune sensing in cancer and sterile inflammation.
Gasdermin D pore formation mediates immunogenic tumor cell death and activates dendritic cells
Nature Immunology (2021)
Demonstrated that GSDMD-mediated pyroptosis releases HMGB1 and ATP from tumor cells, activating DNGR-1+ cDC1s to cross-prime anti-tumor CD8+ T cells.
🏆Awards & Recognition 奖项与荣誉
📄Data Sources 数据来源
Last updated: 2026-01-15 | All information from publicly available academic sources
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