David Steensma
大卫·斯廷斯马
MD
Professor of Medicine; Senior Physician医学教授；高级医师
👥Biography 个人简介
A global authority on MDS and clonal hematopoiesis of indeterminate potential (CHIP) at Dana-Farber. His research connects aging biology with leukemia predisposition, reshaping understanding of MDS pathogenesis and the clinical significance of age-related somatic mutations.
🧪Research Fields 研究领域
🎓Key Contributions 主要贡献
Clonal Hematopoiesis and CHIP
Pioneered clinical characterization of CHIP, demonstrating links between age-related somatic mutations and cardiovascular disease, MDS progression, and leukemia risk, establishing CHIP as a major clinical entity.
MDS Pathogenesis and Classification
Contributed to molecular classification of MDS subtypes, delineating prognostic impact of splicing factor, cohesin, and epigenetic regulator mutations in disease course and therapy selection.
Representative Works 代表性著作
Clonal hematopoiesis and blood-cancer risk inferred from blood DNA sequence
New England Journal of Medicine (2014)
Landmark study defining CHIP prevalence and its association with a 10-fold increased risk of hematologic cancer, establishing CHIP as a recognized premalignant condition.
Myelodysplastic syndromes
New England Journal of Medicine (2015)
Comprehensive clinical review updating pathogenesis, prognostic scoring, and treatment algorithms for MDS, widely used as a reference by practicing hematologists globally.
🏆Awards & Recognition 奖项与荣誉
📄Data Sources 数据来源
Last updated: 2026-01-15 | All information from publicly available academic sources
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Naval Daver
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Courtney DiNardo
The University of Texas MD Anderson Cancer Center
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