Daniel Von Hoff
丹尼尔·冯·霍夫
MD, FACP
Physician-in-Chief and Distinguished Professor首席医师兼杰出教授
👥Biography 个人简介
Daniel Von Hoff is a legendary figure in oncology drug development who conducted the pivotal clinical trials of gemcitabine and nab-paclitaxel in pancreatic cancer, fundamentally advancing treatment for PDAC over four decades.
🧪Research Fields 研究领域
🎓Key Contributions 主要贡献
Gemcitabine Development in PDAC
Led early clinical trials establishing gemcitabine as the first-line standard of care for advanced pancreatic cancer, replacing 5-fluorouracil and improving patient outcomes and quality of life.
Nab-Paclitaxel MPACT Trial
Principal investigator of the MPACT phase III trial that demonstrated nab-paclitaxel plus gemcitabine improved overall survival versus gemcitabine alone, leading to FDA approval in 2013.
Molecular Profiling-Guided Therapy
Pioneered individualized tumor molecular profiling at TGen to match patients with rare mutations to targeted therapies, advancing precision oncology for PDAC and rare cancers.
Representative Works 代表性著作
Gemcitabine versus 5-fluorouracil in previously untreated advanced pancreatic cancer
Journal of Clinical Oncology (1997)
Landmark randomized trial establishing gemcitabine as standard first-line chemotherapy for advanced pancreatic cancer, defining the field for 15 years.
Increased survival in pancreatic cancer with nab-paclitaxel plus gemcitabine
New England Journal of Medicine (2013)
MPACT trial showing nab-paclitaxel plus gemcitabine improved OS, PFS, and response rate over gemcitabine alone in metastatic PDAC.
🏆Awards & Recognition 奖项与荣誉
📄Data Sources 数据来源
Last updated: 2026-01-15 | All information from publicly available academic sources
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