research / researchTumor Microenvironment

Daniel D. De Carvalho

丹尼尔·德·卡瓦略

PhD

🏢Princess Margaret Cancer Centre, University Health Network(玛格丽特公主癌症中心，大学卫生网络)🌐Canada

Senior Scientist; Associate Professor, University of Toronto高级研究员；多伦多大学副教授

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Key Papers

Awards

Key Contributions

👥Biography 个人简介

Leading epigenetics and TME researcher at Princess Margaret Cancer Centre, Toronto. De Carvalho pioneered the viral mimicry concept showing DNMT inhibitors activate endogenous retroviral dsRNA to trigger innate immune sensing, synergizing with checkpoint immunotherapy and reprogramming TAMs within the TME.

🧪Research Fields 研究领域

Cancer Epigenetics癌症表观遗传学

DNMT Inhibitors & ImmunotherapyDNMT抑制剂与免疫治疗

TME Epigenetic ReprogrammingTME表观遗传重编程

Viral Mimicry病毒拟态

DNA Methylation & Immune EvasionDNA甲基化与免疫逃逸

🎓Key Contributions 主要贡献

Viral Mimicry via DNMT Inhibition

Discovered that DNA methyltransferase inhibitors induce expression of endogenous retroviral elements, triggering dsRNA-mediated viral mimicry and type-I interferon signaling that sensitizes tumors to checkpoint immunotherapy.

Epigenetic Reprogramming of the TME

Showed that DNMT inhibitor-driven demethylation reprograms TAM enhancer landscapes toward inflammatory states, linking epigenetic therapy to macrophage re-education and anti-tumor immunity within the tumor microenvironment.

Representative Works 代表性著作

[1]

Induction of viral mimicry by 5-azacytidine in cancer

Cell (2015)

Seminal paper demonstrating DNA demethylation unleashes endogenous retroviral dsRNA, activating innate immune sensors MDA5/MAVS and enhancing immune-mediated tumor killing.

[2]

Epigenetic therapy sensitizes tumors to checkpoint immunotherapy via TME reprogramming

Nature Cancer (2021)

Demonstrated that low-dose DNMT inhibition remodels the immunosuppressive TME including TAM phenotypes, potentiating anti-PD-1 responses in solid tumors.

🏆Awards & Recognition 奖项与荣誉

🏆Canadian Cancer Society Innovation Grant

🏆Ontario Institute for Cancer Research Investigator Award

🏆Gattuso-Slaight Personalized Cancer Medicine Award

📄Data Sources 数据来源

Institution

Last updated: 2026-01-15 | All information from publicly available academic sources

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