Nickolas Papadopoulos

Nickolas Papadopoulos is a Professor at Johns Hopkins University School of Medicine, co-director of the Ludwig Center, and Director of Diagnostic Oncology. He has been a central figure in Johns Hopkins' cancer genetics and liquid biopsy research for over two decades. Papadopoulos co-developed the CancerSEEK blood test — a multi-analyte assay combining ctDNA mutations and protein biomarkers that can detect 8 common cancer types in a single blood draw. This test showed particular power for cancers with no current screening (ovarian, pancreatic, hepatocellular). His laboratory discovered the "mutator phenotype" in colorectal cancer — showing that microsatellite instability (MSI) is caused by defective DNA mismatch repair genes, which later became the basis for pembrolizumab's MSI-H pan-tumor approval.

Nickolas Papadopoulos 是约翰·霍普金斯大学医学院教授，路德维希中心联合主任，以及诊断肿瘤学主任。二十多年来，他一直是约翰·霍普金斯癌症遗传学和液体活检研究的核心人物。 Papadopoulos 共同开发了CancerSEEK血液检测——一种结合ctDNA突变和蛋白质生物标志物的多分析物测定，可以在单次抽血中检测8种常见癌症。