Constantinos Sofocleous
康斯坦丁诺斯·索福克莱奥斯
MD, PhD, FSIR
Chief of Interventional Oncology介入肿瘤学科主任
👥Biography 个人简介
Chief of Interventional Oncology at MSKCC, internationally recognized for advancing ablation of colorectal liver metastases and HCC. Pioneer in ablation margin quantification, biomarker-guided ablation, and combining locoregional therapies with systemic immunotherapy.
🧪Research Fields 研究领域
🎓Key Contributions 主要贡献
Ablation Margin Quantification
Developed 3D volumetric ablation margin assessment tools now used worldwide to predict local tumor progression after hepatic ablation.
Colorectal Liver Metastases
Established MSKCC protocols for ablation of colorectal liver metastases, demonstrating survival benefit comparable to resection in select patients.
Ablation and Immunotherapy Combination
Led translational studies showing ablation-induced immunogenic tumor cell death can potentiate systemic checkpoint inhibitor responses.
Representative Works 代表性著作
Ablation Margin as the Key Factor for Local Tumor Progression After RFA
Journal of Vascular and Interventional Radiology (2022)
Landmark study establishing ablation margin width as primary determinant of local recurrence.
Colorectal Liver Metastases: Thermal Ablation vs. Resection
Annals of Surgical Oncology (2021)
Comparative effectiveness analysis supporting ablation as equivalent to resection for eligible patients.
Combined Ablation and Immunotherapy in Hepatic Malignancies
Cancer Immunology Research (2023)
Demonstrated abscopal immune activation following hepatic thermal ablation combined with anti-PD-1 therapy.
🏆Awards & Recognition 奖项与荣誉
📄Data Sources 数据来源
Last updated: 2026-01-15 | All information from publicly available academic sources
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