Christina Curtis
克里斯蒂娜·柯蒂斯
PhD
Associate Professor, Medicine & Genetics; Endowed Scholar in Translational Medicine医学与遗传学副教授；转化医学讲席学者
👥Biography 个人简介
Christina Curtis leads cancer evolution research at Stanford, combining single-cell genomics, mathematical modeling and large clinical cohorts to understand how breast cancers evolve, diversify and evade treatment. She co-led the METABRIC study defining molecular subtypes of breast cancer.
🧪Research Fields 研究领域
🎓Key Contributions 主要贡献
METABRIC Breast Cancer Subtypes
Co-led METABRIC, the landmark integrative genomic and transcriptomic study of 2000 breast tumors that identified 10 molecular subtypes with distinct clinical outcomes.
Cancer Evolutionary Dynamics
Demonstrated that breast cancers undergo punctuated evolution with early genomic diversification, reshaping understanding of when metastatic potential is acquired.
Single-Cell Cancer Genomics
Developed computational methods to reconstruct tumor phylogenies from single-cell DNA sequencing, revealing subclonal selection and therapeutic resistance mechanisms.
Representative Works 代表性著作
The genomic and transcriptomic architecture of 2,000 breast tumours reveals novel subgroups
Nature (2012)
METABRIC study defining 10 integrative molecular subtypes of breast cancer with prognostic and therapeutic relevance.
Genomic characterization of metastatic breast cancers
Nature (2019)
Multi-institutional analysis of 617 metastatic breast cancer genomes revealing genomic evolution and acquired resistance mechanisms.
Punctuated copy number evolution and clonal stasis in triple-negative breast cancer
Nature Genetics (2016)
Revealed punctuated genomic evolution in early breast cancer development with implications for metastasis timing.
🏆Awards & Recognition 奖项与荣誉
📄Data Sources 数据来源
Last updated: 2026-01-15 | All information from publicly available academic sources
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