research / researchCancer Metabolism

Chi Van Dang

邓志远

MD, PhD

🏢Ludwig Institute for Cancer Research / University of Pennsylvania(路德维希癌症研究所/宾夕法尼亚大学)🌐USA

Scientific Director, Ludwig Institute for Cancer Research路德维希癌症研究所科学主任

105

h-index

Key Papers

Awards

Key Contributions

👥Biography 个人简介

Chi Van Dang, MD, PhD is Scientific Director of the Ludwig Institute for Cancer Research and a world authority on how the MYC oncogene drives metabolic reprogramming in cancer. His laboratory demonstrated that MYC directly activates glutamine metabolism and the Warburg effect, establishing oncogene-mediated metabolic transformation as a cancer hallmark and therapeutic vulnerability.

🧪Research Fields 研究领域

MYC Oncogene MetabolismMYC致癌基因代谢

Glutamine Metabolism谷氨酰胺代谢

Hypoxia and HIF缺氧与HIF

Warburg EffectWarburg效应

Cancer Metabolic Reprogramming癌症代谢重编程

🎓Key Contributions 主要贡献

MYC and Glutamine Metabolism

Demonstrated that the MYC oncogene transcriptionally activates glutamine catabolism genes, establishing glutamine as a key bioenergetic and biosynthetic fuel in MYC-driven cancers.

MYC and HIF Interaction

Discovered that MYC and HIF-1α cooperate under hypoxic conditions to amplify Warburg metabolism, revealing how oncogenic and environmental signals converge to reprogram cancer metabolism.

Representative Works 代表性著作

[1]

c-Myc target genes involved in cell growth, apoptosis, and metabolism

Molecular and Cellular Biology (1999)

Comprehensive mapping of MYC target genes linked to proliferative metabolism, establishing metabolic gene regulation as a core MYC function.

[2]

MYC-induced cancer cell energy metabolism and therapeutic opportunities

Clinical Cancer Research (2012)

Translated mechanistic insights on MYC metabolic reprogramming into therapeutic strategies targeting glutamine and lactate dehydrogenase.

🏆Awards & Recognition 奖项与荣誉

🏆AACR Award for Outstanding Achievement in Cancer Research

🏆Member, National Academy of Medicine

🏆Member, National Academy of Sciences

🏆The Johns Hopkins Distinguished Service Award

📄Data Sources 数据来源

Institution

Last updated: 2026-01-15 | All information from publicly available academic sources

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