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research / researchproteomics biomarkers

Amanda Paulovich

阿曼达·波洛维奇

MD, PhD

🏢Fred Hutchinson Cancer Center(弗雷德·哈钦森癌症中心)🌐USA

Member and Full Professor, Human Biology Division人类生物学部资深成员及教授

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Key Papers
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Awards
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Key Contributions

👥Biography 个人简介

Amanda Paulovich is a leader in clinical proteomics who has built rigorous mass spectrometry-based assay platforms for cancer biomarker validation. As a key contributor to the NCI Clinical Proteomic Tumor Analysis Consortium (CPTAC), she has driven standardization of proteomics methods enabling multi-site reproducibility. Her laboratory pioneered selected reaction monitoring (SRM) assays as quantitative protein biomarker verification tools, bridging proteomic discovery to clinical application. Paulovich has developed plasma-based protein biomarkers for early detection of multiple cancer types including ovarian and pancreatic cancer.

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🧪Research Fields 研究领域

cancer proteomics癌症蛋白质组学
mass spectrometry质谱分析
targeted proteomics靶向蛋白质组学
SRM/MRM assaysSRM/MRM检测
CPTAC consortiumCPTAC联盟

🎓Key Contributions 主要贡献

CPTAC Proteomics Standardization

Led development of standardized proteomics assay protocols for the NCI CPTAC program, enabling reproducible multi-institutional cancer proteomics research.

SRM Assay Development

Pioneered application of SRM/MRM mass spectrometry for quantitative protein biomarker verification, providing a path from proteomics discovery to clinical validation.

Representative Works 代表性著作

[1]

Clinical-Grade Proteogenomics of Breast Cancer Subtypes

Nature (2020)

CPTAC comprehensive proteogenomic characterization of breast cancer.

[2]

Quantification of Cancer Biomarkers in Serum Using SRM Assays

Molecular & Cellular Proteomics (2012)

Framework for targeted mass spectrometry biomarker verification.

🏆Awards & Recognition 奖项与荣誉

🏆NCI CPTAC Excellence Award
🏆American Association for Cancer Research Women in Cancer Research Scholar Award

📄Data Sources 数据来源

Institution

Last updated: 2026-01-15 | All information from publicly available academic sources

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