Carlo M. Croce
卡洛·克罗切
MD
Professor and Chair, Department of Cancer Biology and Genetics; Director, Human Cancer Genetics Program癌症生物学与遗传学系教授兼系主任；人类癌症遗传学项目主任
👥Biography 个人简介
Seminal figure in microRNA cancer research who discovered that miR-15a and miR-16 are deleted in CLL, the first demonstration of miRNA involvement in human cancer. His work established the oncomiR field.
🧪Research Fields 研究领域
🎓Key Contributions 主要贡献
miRNA and CLL
First demonstrated that miR-15a and miR-16 are deleted at chromosome 13q14 in the majority of CLL patients, establishing miRNAs as tumor suppressors in human cancer.
OncomiR Catalog
Systematically identified a comprehensive landscape of miRNAs altered in human cancers, creating the oncomiR concept and opening cancer RNA as a therapeutic target class.
Representative Works 代表性著作
Frequent deletions and down-regulation of micro-RNA genes miR15 and miR16 at 13q14 in chronic lymphocytic leukemia
PNAS (2002)
Landmark paper demonstrating miRNA deletion drives CLL, the first miRNA-cancer link in humans.
MicroRNA gene expression deregulation in human breast cancer
Cancer Research (2005)
Comprehensive profiling of miRNA alterations in breast cancer defining a new cancer biomarker landscape.
miR-15 and miR-16 induce apoptosis by targeting BCL2
PNAS (2005)
Mechanistic proof that miR-15a/16 suppress BCL2 to induce apoptosis in leukemia.
🏆Awards & Recognition 奖项与荣誉
📄Data Sources 数据来源
Last updated: 2026-01-15 | All information from publicly available academic sources
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Andrew H. Beck
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关注 卡洛·克罗切 的研究动态
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留下邮箱，当我们发布与 Carlo M. Croce（The Ohio State University Comprehensive Cancer Center）相关的新研究或访谈时，我们会通知你。
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