Bert Vogelstein
伯特·沃格尔斯坦
MD
Clayton Professor of Oncology; Investigator, Howard Hughes Medical Institute; Director, Ludwig Center at Johns Hopkins克莱顿肿瘤学教授；HHMI研究员；约翰斯·霍普金斯路德维希中心主任
👥Biography 个人简介
Bert Vogelstein is one of the most cited scientists in history, renowned for elucidating the multi-step genetic model of colorectal cancer development and establishing TP53 as the most frequently mutated gene in human cancer. His laboratory pioneered cancer genome sequencing, the concept of driver versus passenger mutations, and has made transformative contributions to early cancer detection through liquid biopsy approaches. The Vogelgram model of colorectal carcinogenesis remains a canonical framework for understanding how normal cells evolve into malignancy.
🧪Research Fields 研究领域
🎓Key Contributions 主要贡献
Multi-Step Colorectal Carcinogenesis
Established the genetic roadmap for colorectal cancer progression (APC → KRAS → SMAD4 → TP53), creating the first molecular model of stepwise tumor evolution.
TP53 as Universal Tumor Suppressor
Demonstrated that TP53 is mutated in over 50% of human cancers, transforming understanding of tumor suppressor pathways and p53 as the 'guardian of the genome.'
Cancer Genome Landscape
Led landmark sequencing efforts defining the mutational landscape of breast, colorectal, pancreatic, and brain cancers, establishing the driver/passenger mutation framework.
Liquid Biopsy for Early Detection
Pioneered circulating tumor DNA analysis for ultra-early multi-cancer detection, advancing the CancerSEEK blood test concept.
Representative Works 代表性著作
Genetic Alterations during Colorectal-Tumor Development
New England Journal of Medicine (1988)
Seminal paper establishing the multi-step genetic model of colorectal carcinogenesis that remains foundational to cancer biology.
The Genomic Landscapes of Human Breast and Colorectal Cancers
Science (2006)
Comprehensive sequencing of breast and colorectal cancer genomes, defining the catalog of somatic mutations driving common solid tumors.
Detection and Localization of Surgically Resectable Cancers with a Multi-Analyte Blood Test
Science (2018)
Introduced CancerSEEK, a single blood test capable of detecting eight common cancer types at early stages.
🏆Awards & Recognition 奖项与荣誉
📄Data Sources 数据来源
Last updated: 2026-01-15 | All information from publicly available academic sources
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