Andrew Rhim
安德鲁·林
MD
Associate Professor, Department of Gastroenterology, Hepatology & Nutrition胃肠病学、肝病学与营养学系副教授
👥Biography 个人简介
Andrew Rhim is a leading investigator in pancreatic cancer tumor microenvironment biology, known for elucidating the role of desmoplasia and cancer-associated fibroblasts in promoting drug resistance and immune evasion in PDAC.
🧪Research Fields 研究领域
🎓Key Contributions 主要贡献
Desmoplasia and Drug Resistance
Demonstrated that the dense desmoplastic stroma in PDAC acts as a physical barrier to drug delivery and immune infiltration, providing mechanistic rationale for stromal targeting strategies.
Epithelial-Mesenchymal Transition
Identified circulating pancreatic epithelial cells during early PDAC progression, revealing EMT as an early dissemination event and potential early detection biomarker.
CAF Heterogeneity
Characterized functionally distinct cancer-associated fibroblast subpopulations in PDAC stroma, revealing myofibroblastic vs. inflammatory CAF roles in tumor promotion and restraint.
Representative Works 代表性著作
EMT and dissemination precede pancreatic tumor formation
Cell (2012)
Revealed that pancreatic epithelial cells undergo EMT and enter circulation before overt tumor formation, challenging the late-dissemination model of PDAC.
Stromal elements act to restrain rather than support pancreatic ductal adenocarcinoma
Cancer Cell (2014)
Showed that depleting sonic hedgehog-driven stroma paradoxically accelerated PDAC, redefining the stromal targeting paradigm.
🏆Awards & Recognition 奖项与荣誉
📄Data Sources 数据来源
Last updated: 2026-01-15 | All information from publicly available academic sources
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Johanna Bendell
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