Almut Schulze
阿尔穆特·舒尔茨
PhD
Professor and Chair of Biochemistry and Molecular Biology; Head, Division of Tumor Metabolism生物化学与分子生物学教授兼主任；肿瘤代谢部门负责人
👥Biography 个人简介
Almut Schulze is a leading expert in lipid metabolism in cancer, best known for her work on fatty acid synthase (FASN) and how oncogenes such as MYC reprogram lipid biosynthesis to support tumor growth. Her research bridges cancer cell biology with therapeutic strategies targeting lipogenic pathways.
🧪Research Fields 研究领域
🎓Key Contributions 主要贡献
MYC and Lipid Biosynthesis
Established that MYC oncogene transcriptionally activates lipid biosynthesis genes including FASN, driving de novo lipogenesis essential for cancer cell membrane production and signaling.
FASN as Therapeutic Target
Demonstrated that FASN inhibition suppresses tumor growth in MYC-amplified cancers and identified biomarkers of sensitivity, advancing FASN inhibitors toward clinical development.
Lipid Droplets in Cancer
Revealed that lipid droplet accumulation in cancer cells functions as a metabolic buffer that supports survival under nutrient stress and promotes resistance to therapy.
Representative Works 代表性著作
Fatty acid synthesis is a key regulator of the unfolded protein response
Journal of Cell Biology (2009)
Linked fatty acid synthesis to ER homeostasis, explaining why lipogenesis inhibition triggers ER stress and cancer cell death.
MYC regulates the transcription of fatty acid metabolism genes
Cancer Research (2012)
Comprehensive analysis of MYC-driven lipid gene expression programs, identifying FASN and related enzymes as direct MYC targets.
Targeting lipid metabolism in cancer
Nature Reviews Drug Discovery (2021)
Authoritative review of lipid metabolic vulnerabilities in cancer and clinical progress of lipid metabolism inhibitors.
🏆Awards & Recognition 奖项与荣誉
📄Data Sources 数据来源
Last updated: 2026-01-15 | All information from publicly available academic sources
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