Almut Schulze
阿尔穆特·舒尔茨
PhD
Professor of Biochemistry and Molecular Biology; Division Head, Theodor Boveri Institute生物化学与分子生物学教授；特奥多尔·波维里研究所部门主任
👥Biography 个人简介
Almut Schulze, PhD is a Professor at the University of Würzburg and a leading European expert in cancer lipid metabolism. Her research has defined how de novo lipogenesis, driven by fatty acid synthase (FASN) and lipogenic transcription programs, supports membrane biogenesis and signaling in rapidly proliferating cancer cells, with implications for therapeutic targeting.
🧪Research Fields 研究领域
🎓Key Contributions 主要贡献
De Novo Lipogenesis in Cancer
Characterized how FASN and the SREBP lipogenic program are activated by oncogenic signals to support cancer cell membrane production and post-translational protein lipidation required for proliferation and survival.
MYC Regulation of Lipid Metabolism
Demonstrated that MYC directly controls lipogenic gene expression, linking oncogenic transcription factor activity to lipid anabolism as a cancer growth dependency.
Representative Works 代表性著作
MYC regulates fatty acid biosynthesis and lipid metabolism in cancer cells
Oncogene (2010)
Established that MYC transcriptionally activates lipogenic enzymes, connecting oncogenic signaling to cancer-specific lipid anabolism.
Lipid droplets protect cancer cells from saturated fatty acid-induced lipotoxicity
Nature Communications (2020)
Revealed lipid droplet dynamics as an adaptive mechanism enabling cancer cell survival under lipotoxic stress in the tumor microenvironment.
🏆Awards & Recognition 奖项与荣誉
📄Data Sources 数据来源
Last updated: 2026-01-15 | All information from publicly available academic sources
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