Alexey V. Danilov
阿列克谢·达尼洛夫
MD, PhD
Associate Director, Toni Stephenson Lymphoma Center; Professor, Department of Hematology and Hematopoietic Cell Transplantation托尼·斯蒂芬森淋巴瘤中心副主任，血液学教授
👥Biography 个人简介
Dr. Alexey Danilov is a leading physician-scientist in CLL and indolent B-cell lymphomas, recognized for clinical and translational research on BTK inhibitors and PI3Kδ inhibitors. His laboratory studies mechanisms of drug resistance and microenvironmental signaling, informing rational combination strategies for CLL and mantle cell lymphoma.
🧪Research Fields 研究领域
🎓Key Contributions 主要贡献
BTK Inhibitor Resistance in CLL
Identified key resistance mechanisms to ibrutinib including BTK C481 mutations and alternative BCR pathway activation, providing rationale for next-generation non-covalent BTK inhibitors such as pirtobrutinib.
PI3Kδ Inhibitor Biology
Elucidated mechanisms of idelalisib and umbralisib activity in CLL and follicular lymphoma, and described immune-related toxicity mechanisms leading to improved patient selection and monitoring strategies.
Representative Works 代表性著作
Mechanisms of Resistance to BTK Inhibition in CLL
Blood (2018)
Characterized acquired resistance mutations and bypass signaling pathways in CLL patients progressing on ibrutinib, guiding next-generation BTK inhibitor development.
Umbralisib Monotherapy in Patients with Relapsed/Refractory CLL
Leukemia (2021)
Demonstrated clinical activity of the next-generation PI3Kδ inhibitor umbralisib with an improved tolerability profile compared to first-generation PI3K inhibitors.
🏆Awards & Recognition 奖项与荣誉
📄Data Sources 数据来源
Last updated: 2026-01-15 | All information from publicly available academic sources
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