research / researchTumor Microenvironment

Alberto Mantovani

阿尔贝托·曼托瓦尼

🏢Humanitas University & IRCCS Humanitas Research Hospital(胡马尼塔斯大学及IRCCS胡马尼塔斯研究医院)🌐Italy

Scientific Director, IRCCS Humanitas Research Hospital; Professor of PathologyIRCCS胡马尼塔斯研究医院科学主任；病理学教授

175

h-index

Key Papers

Awards

Key Contributions

👥Biography 个人简介

Founding father of tumor macrophage polarization biology at Humanitas University, Milan, and one of the most cited scientists in the world. Mantovani defined the M1/M2 macrophage paradigm, characterized pentraxin-3 in innate immunity, and established TAMs as orchestrators of tumor-promoting inflammation.

🧪Research Fields 研究领域

TAM M1/M2 PolarizationTAM M1/M2极化

Pentraxin-3 & Innate Immunity五聚素-3与先天免疫

Tumor-Promoting Inflammation促瘤炎症

IL-10 & TGF-β SignalingIL-10与TGF-β信号

Cancer Hallmarks癌症标志

🎓Key Contributions 主要贡献

M1/M2 Macrophage Polarization Paradigm

Formalized the M1/M2 macrophage polarization concept showing tumors preferentially induce M2-like immunosuppressive TAMs via IL-4, IL-10, and TGF-β, establishing the dominant framework for understanding TAM biology in cancer.

Pentraxin-3 & Innate Tumor Immunity

Identified pentraxin-3 as a non-redundant humoral innate immunity component with tumor-suppressive functions, characterizing its distinct signaling properties compared to C-reactive protein in inflammatory circuits.

Representative Works 代表性著作

[1]

Macrophage polarization: tumor-associated macrophages as a paradigm for polarized M2 mononuclear phagocytes

Trends in Immunology (2002)

Seminal paper establishing the M2 paradigm for TAMs, cited thousands of times and foundational to all subsequent TME immunology research worldwide.

[2]

Cancer-related inflammation

Nature (2008)

Landmark review establishing inflammation as a hallmark of cancer, with TAMs as central orchestrators linking chronic immune activation to tumor progression.

🏆Awards & Recognition 奖项与荣誉

🏆William B. Coley Award for Distinguished Research in Basic and Tumor Immunology

🏆Robert Koch Prize

🏆Elected Member, National Academy of Sciences (USA)

🏆Elected Member, Royal Society (London)

🏆AACR Pezcoller Foundation International Award

📄Data Sources 数据来源

Institution

Last updated: 2026-01-15 | All information from publicly available academic sources

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